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The effect starts already in 20 minutes after ingestion and lasts up to 6 hours, sometimes up to 12 hours.

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See the Medication Guide section called “How should I take Promethazine Hydrochloride and Codeine Phosphate Oral
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Take this medication by mouth with or without food, usually every 4 to 6 hours as needed with a full glass of water (8 ounces or 240 milliliters) or as directed by your doctor like Quagen Cough syrup.

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firstly, Quagen Pharma has announced the introduction of its promethazine and codeine syrup (Cetirizine Hydrochloride Oral Solution,)

thirdly, Promethazine – causes sedative effect, has antiemetic effect. It has also pronounced to be an adrenoblocking remedy, which moderates peripheral and central anticholinergic action. The effect starts already in 20 minutes after ingestion and lasts up to 6 hours, sometimes up to 12 hours.

Take Promethazine Hydrochloride and Codeine Phosphate Oral Solution exactly as prescribed by your healthcare provider. If you take the wrong dose of Promethazine Hydrochloride and Codeine Phosphate Oral Solution you could overdose and die. See the Medication Guide section called “How should I take Promethazine Hydrochloride and Codeine Phosphate Oral
Solution?” for important information about how to take Promethazine Hydrochloride and Codeine Phosphate Oral Solution correctly. Avoid driving a car or operating machinery during treatment with Promethazine Hydrochloride
and Codeine Phosphate Oral Solution.